Pain Reprocessing Therapy (PRT) is a system of psychological techniques that retrains the brain to interpret and respond to signals from the body properly, subsequently breaking the cycle of chronic pain.

A randomized controlled study at the University of Colorado Boulder validated Pain Reprocessing Therapy as the most effective current treatment for chronic pain. In the study, there were 100 chronic back pain patients. Half of them received PRT twice a week for four weeks, and half of them received treatment as usual. In the PRT group, 98% of patients improved and 66% of patients were pain-free or nearly pain-free at the end of treatment. These outcomes were largely maintained one year later.